product

A landmark clinical trial has shown that a compound in marijuana can ease life-threatening seizures in children with a rare and devastating form of epilepsy.

62172e72344a35143ccadd05ad42cffc.jpg?b=tCannabidiol -- a non-intoxicating chemical -- reduced seizure frequency by 39 percent in patients with Dravet Syndrome, researchers report.

This is the first randomized, controlled trial to show that cannabidiol (CBD) can help control seizures in some people with epilepsy, said study author Dr. Orrin Devinsky. He is director of the Comprehensive Epilepsy Center at NYU Langone Medical Center in New York City.

"It's a big landmark in the scientific study of cannabis, and it's a major landmark in epilepsy care," Devinsky said. "After four millennia of using cannabis to treat epilepsy, we now have for the first time scientifically rigorously obtained data that this specific compound works in this specific form of epilepsy."

More in Marijuana Nation

Brandy Fureman, vice president of research and new therapies for the Epilepsy Foundation, agreed that the new trial provides "gold standard" evidence of cannabidiol's effectiveness.

"We now have strong evidence that CBD [cannabidiol] can be helpful for some people with Dravet Syndrome," Fureman said. "This trial provides important information for doctors and families who are trying to decide if CBD should be tried in their child's particular case, how it can be administered safely, and what side effects to watch out for."

The clinical trial relied on a liquid formulation of cannabidiol called Epidiolex, which was developed by British company GW Pharmaceuticals.

Epidiolex has not been approved by the U.S. Food and Drug Administration. GW Pharmaceuticals -- which paid for the clinical trial -- expects to file for FDA approval of the drug this year.

In the trial, Devinsky and his colleagues recruited 120 children and teenagers with Dravet Syndrome, which generally starts causing severe seizures within the first year of life. The seizures often are prolonged and repetitive; 1 in 5 children with Dravet Syndrome do not live to see age 20, Devinsky said.

The patients, ranging in age from 2 to 18, were randomly assigned to receive every day either 20 milligrams of liquid Epidiolex or a placebo, on top of their usual medication. The study took place across 23 sites in the United States and Europe, and lasted 14 weeks.

Children receiving Epidiolex experienced fewer seizures, going from an average of 12 convulsive seizures a month before the study to about six seizures a month. Three patients' seizures stopped entirely.

At the same time, children in the placebo group only had a slight reduction in seizures, from about 15 to 14 seizures a month.

More than 9 out of 10 children did experience side effects from treatment with Epidiolex, the researchers found. The most common side effects were vomiting, fatigue and fever.

Although these symptoms generally were mild to moderate, eight children in the Epidiolex group withdrew from the trial due to side effects, compared to one patient in the placebo group.

The study appears in the May 25 issue of the New England Journal of Medicine.

Despite the side effects, Epidiolex seems as safe as other epilepsy medications, said Dr. Samuel Berkovic, director of the University of Melbourne's Epilepsy Research Center in Australia.

"Side effects are always an issue, but the drug was tolerated about as well as conventional anti-epileptic drugs," said Berkovic, who wrote an editorial accompanying the clinical trial report.

"Like other epilepsy medications, CBD appears to work for some people and not for others," Fureman said. "Like other epilepsy treatments, there are side effects of CBD that should be considered."

Cannabidiol-based treatments are available in the 29 states that have approved medical marijuana, Devinsky said.

The problem is that these products aren't manufactured under strict FDA oversight, and might contain varying levels of cannabidiol. The products also might contain THC, 해적바둑이게임 the biochemical in marijuana that produces a high, Devinsky said.

>"Hopefully, in the next year to two years Epidiolex would get FDA approval, and then this drug could be available in pharmacies and people could have it covered by their health insurance," Devinsky said.

>"In the interim, people are getting something like this from medical dispensaries in states with legalized medical marijuana," he continued. "The question is, how different are batches to batches."

List of Articles
번호 제목 글쓴이 날짜 조회 수
13297 Italians Anxious For Wrecked Liner To Disappear KayleneMccain1917 2019.09.08 1
13296 Earlier This Week, Attacks On A Government Security Compound And The Country's Central Bank Killed Nine And Injured 100 JeniferAngulo6757604 2019.09.08 1
13295 เดรสออกงาน ReginaRaines79039 2019.09.08 1
13294 Khánh Chó Lừa đảo PhilippRotton859455 2019.09.08 1
13293 How To Get Counterfeit Banknotes, Where To Buy Counterfeit Banknotes AishaVictor0960960 2019.09.08 1
13292 All Boats Will Be Decorated, Including Kayaks And Canoes JaunitaGlover4605040 2019.09.08 1
13291 Rights Groups Are Worried About What This Move May Mean For A Number Of Female Women's Rights Activists Who Have Been Held Without Charge By Saudi Authorities Following A Crackdown In May CandraKolios305 2019.09.08 1
13290 What Are The Different Types Of Carpet For The Home? MollieBergman7466851 2019.09.08 1
13289 2008. Reps For The Show And Cowell Have Yet To Provide Comment. "X Factor" Will Premiere This September On Fox. ErinGoad97068709793 2019.09.08 1
13288 Expected To Make A Full Recovery|Sources Say The Daughter Swerved To Avoid A Collision In Her Driving Lane And The Automobile Rolled Over On To The Side Of The Freeway|His 11-year-old Son Was Also In The EduardoChurch99322022 2019.09.08 1
13287 Opinions, Recommendations And Test Outcomes JackYsq123696073 2019.09.08 1
13286 21 MarilynHailes255 2019.09.08 1
13285 The Victims Were On Their Way Home From A Religious Pilgrimage In Iraq When Rebels Intercepted Their Vehicles In Syria's Aleppo Province, According To The Officials, Who Asked For Anonymity Because They Were Not Authorized To Speak Publicly SusanaSteigrad20935 2019.09.08 1
13284 サッカーベッティング|最高のサッカーベッティングサイト|サッカーオンラインでベット|最高のオンラインブックメーカー TedBurbach7566710961 2019.09.08 1
13283 Khánh Chó Lừa đảo PhilippRotton859455 2019.09.08 1
13282 Sheahan, "a Bindle Of Cocaine In A Plastic Bag Came Out Of Her Purse" In RozellaLombard37 2019.09.08 1
13281 The Options For You Opt This Mini Tv Box HermelindaDarbyshire 2019.09.08 1
13280 At Least 55 American Troops Have Been Killed Since July 2010 MaribelDodery2490 2019.09.08 1
13279 Sheahan, "a Bindle Of Cocaine In A Plastic Bag Came Out Of Her Purse" In AlfieWwb2518998537 2019.09.08 1
13278 Hopqua, Hop Qua Sinh Nhat, Hop Qua Nho, Hop Qua Size Lon, Hop Qua Dep, Hop Qua Lon, Hop Qua Vuong, Hop Qua Giay, Hop Qua Gia Re , Hop Qua SteveSoileau371 2019.09.08 1
Board Pagination Prev 1 ... 3 4 5 6 7 8 9 10 11 12 ... 672 Next
/ 672